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The present invention is directed to methods for treating premenstrual disorders in human females In particular, the present invention is directed to methods for treating premenstrual disorders such as a premenstrual dysphoric disorder and/or a premenstrual syndrome by peripheral administration of a botulinum toxin.Premenstrual Disorders Emotional, physical, and functional symptoms are common during a premenstrual period in as many as 75% of women of reproductive age.is not available to customers or patients who are located outside of the United States or U. military personnel permanently assigned or on temporary duty overseas, please call our Customer Service team at 1-800-SHOP CVS (1-800-746-7287) if you need assistance with your order.Routine scalp or scalp-sphenoidal recordings are usually sufficient for localization.A high resolution MRI scan is routinely used to identify structural lesions.

These neurotransmitter changes and declines of sex hormones may lead to both peripheral and central sensitization Current treatment of PMDD and PMS is based on the hypothesis that neurotransmitter & hormonal fluctuations are in part responsible for the over 150 reported premenstrual symptoms associated with PMS and PMDD.

Other causes of epilepsy include stroke, infection and genetic susceptibility. et al., Harrison's Principles of Internal Medicine, Mc Graw-Hill, 14Edition (1998), page 2321.

Antiepileptic drug therapy is the mainstay of treatment for most patients with epilepsy and a variety of drugs have been used. Twenty percent of patients with epilepsy are resistant to drug therapy despite efforts to find an effective combination of antiepileptic drugs. Video-EEC monitoring can be used to define the anatomic location of the seizure focus and to correlate the abnormal electrophysiologic activity with behavioral manifestations of the seizure.

Functional Imaging studies such as SPECT and PET are adjunctive tests that can help verify the localization of an apparent epileptogenic region with an anatomic abnormality.

Once the presumed location of the seizure onset is identified, additional studies, including neuropsychological testing and the intracarotid amobarbital test (Wada's test) can be used to assess language and memory localization and to determine the possible functional consequences of surgical removal of the epileptogenic region.

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