Peptidylglycine alpha amidating enzyme

Release of peptides from large dense core vesicles (LDCVs; also known as secretory granules) occurs in dendrites, the cell soma, along the axon and at the nerve terminal (]) than release of small synaptic vesicles and many neuropeptides must diffuse some distance before encountering the receptors that identify their targets.

Since the synthesis, storage and secretion of all neuropeptides require a common set of enzymes, manipulation of the genes encoding these enzymes has provided insight into the most sensitive elements of the peptidergic system.

The m RNAs encoding prepropeptides are translated in the cell soma.Pathways for production, storage and secretion of peptides in neurons The biosynthetic pathway for a model neuropeptide, neuropeptide Y, is outlined with the necessary enzymatic steps.The key transporters/chaperones involved in providing copper to PAM are indicated.In , deletion of the PAM gene results in the absence of amidated peptides and in lethality at an early larval stage (Jiang et al., 2000; Kolhekar et al., 1997).Similarly, elimination of the murine PAM gene results in the absence of enzymatic activity and in lethality at mid-gestation (Czyzyk et al., 2005).

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